Zhihong Li Selected Research

2- hydroxy- 1- (2- ((9- (4- methylcyclohexyl)- 9H- pyrido(4',3'- 4,5)pyrrolo(2,3- d)pyrimidin- 2- yl)amino)- 7,8- dihydro- 1,6- naphthyridin- 6(5H)- yl)ethanone

2/2015	AMG 925 is a dual FLT3/CDK4 inhibitor with the potential to overcome FLT3 inhibitor resistance in acute myeloid leukemia.
4/2014	Preclinical evaluation of AMG 925, a FLT3/CDK4 dual kinase inhibitor for treating acute myeloid leukemia.

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Zhihong Li Research Topics

Disease

78	Neoplasms (Cancer) 12/2023 - 02/2002
24	Osteosarcoma (Osteogenic Sarcoma) 08/2023 - 01/2012
15	Infections 11/2023 - 02/2006
15	Hypoxia (Hypoxemia) 09/2023 - 12/2014
10	Neoplasm Metastasis (Metastasis) 12/2023 - 02/2002
10	Anemia 11/2023 - 11/2012
9	Inflammation (Inflammations) 01/2024 - 01/2015
9	Sarcoma (Soft Tissue Sarcoma) 01/2023 - 10/2014
7	Osteoarthritis 03/2024 - 01/2019
6	Breast Neoplasms (Breast Cancer) 12/2021 - 02/2002
5	Hepatocellular Carcinoma (Hepatoma) 12/2023 - 03/2012
5	Leukemia 07/2023 - 02/2013
5	Chondrosarcoma 02/2023 - 07/2016
5	Carcinogenesis 10/2022 - 09/2015
5	Wounds and Injuries (Trauma) 01/2022 - 07/2013
5	Hemorrhage 01/2022 - 05/2012
5	Cerebral Hemorrhage 01/2018 - 01/2015
4	Squamous Cell Carcinoma of Head and Neck 05/2022 - 12/2015
4	Necrosis 09/2021 - 12/2012
4	Ischemia 01/2020 - 01/2014
4	Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung) 12/2018 - 04/2014
4	Mitochondrial Diseases (Mitochondrial Disease) 01/2016 - 04/2010
3	Pain (Aches) 01/2024 - 04/2020
3	Type 2 Diabetes Mellitus (MODY) 12/2023 - 01/2021
3	Obesity 12/2023 - 08/2009
3	Ulcerative Colitis 08/2022 - 01/2017
3	Osteoporosis 01/2022 - 01/2020
3	Hypertension (High Blood Pressure) 01/2022 - 01/2015
3	Prostatic Neoplasms (Prostate Cancer) 01/2022 - 01/2013
3	Rheumatoid Arthritis 09/2021 - 10/2015
3	Body Weight (Weight, Body) 07/2020 - 04/2014
3	Glioma (Gliomas) 10/2017 - 01/2017
2	Hematoma 01/2024 - 09/2017
2	Liver Diseases (Liver Disease) 12/2023 - 09/2021
2	Uterine Cervical Neoplasms (Cancer of the Cervix) 07/2023 - 10/2021
2	Lung Neoplasms (Lung Cancer) 07/2023 - 03/2015
2	Atrial Fibrillation 06/2023 - 01/2021
2	Fibrosis (Cirrhosis) 01/2023 - 06/2016
2	Gastroesophageal Reflux (GERD) 01/2023 - 11/2021
2	Esophageal Squamous Cell Carcinoma 11/2022 - 09/2015
2	Venous Thromboembolism 05/2022 - 11/2014
2	Gestational Diabetes (Gestational Diabetes Mellitus) 01/2022 - 09/2018
2	Carcinoma (Carcinomatosis) 01/2022 - 12/2020
2	Ovarian Neoplasms (Ovarian Cancer) 02/2021 - 05/2016

Drug/Important Bio-Agent (IBA)

23	Proteins (Proteins, Gene)FDA Link 12/2023 - 01/2010
21	Biomarkers (Surrogate Marker)IBA 10/2023 - 01/2017
16	Long Noncoding RNAIBA 01/2023 - 01/2015
8	Prolyl Hydroxylases (Prolyl Hydroxylase)IBA 11/2023 - 01/2019
8	RNA (Ribonucleic Acid)IBA 08/2023 - 01/2020
7	DNA (Deoxyribonucleic Acid)IBA 01/2022 - 02/2002
7	Small Interfering RNA (siRNA)IBA 01/2019 - 02/2013
6	Therapeutic UsesIBA 10/2023 - 12/2016
6	Cisplatin (Platino)FDA LinkGeneric 01/2021 - 01/2012
6	MicroRNAs (MicroRNA)IBA 12/2020 - 09/2015
5	Circular RNAIBA 10/2023 - 12/2020
5	CateninsIBA 01/2022 - 05/2016
4	Reactive Oxygen Species (Oxygen Radicals)IBA 01/2023 - 01/2015
4	Erythropoietin FDA Link 08/2022 - 01/2020
4	Prolyl-Hydroxylase InhibitorsIBA 12/2021 - 01/2018
4	Oxygen (Dioxygen)IBA 10/2021 - 12/2014
3	Messenger RNA (mRNA)IBA 12/2023 - 02/2013
3	Doxorubicin (Adriamycin)FDA LinkGeneric 08/2023 - 12/2016
3	Warfarin (Coumadin)FDA LinkGeneric 06/2023 - 01/2021
3	Peptides (Polypeptides)IBA 02/2023 - 09/2017
3	AntibodiesIBA 01/2023 - 03/2012
3	CytokinesIBA 12/2022 - 03/2010
3	EnzymesIBA 08/2022 - 08/2007
3	Indicators and Reagents (Reagents)IBA 01/2022 - 01/2015
3	Phosphotransferases (Kinase)IBA 12/2020 - 04/2014
3	Matrix Metalloproteinases (MMPs)IBA 12/2020 - 07/2013
3	AdiponectinIBA 01/2019 - 10/2015
3	AntioxidantsIBA 01/2018 - 01/2015
2	Antihypertensive Agents (Antihypertensives)IBA 03/2024 - 01/2015
2	Blood Glucose (Blood Sugar)IBA 12/2023 - 07/2020
2	Protons (Proton)IBA 09/2023 - 01/2020
2	SmokeIBA 07/2023 - 09/2021
2	Hemostatics (Antihemorrhagics)IBA 04/2023 - 08/2022
2	hesperetinIBA 04/2023 - 01/2019
2	palbociclibIBA 02/2023 - 01/2019
2	Cyclin-Dependent Kinase 4IBA 02/2023 - 01/2019
2	Immunoglobulin G (IgG)IBA 01/2023 - 08/2007
2	AldehydesIBA 11/2022 - 11/2022
2	Fluorescent Dyes (Fluorescent Probes)IBA 04/2022 - 01/2016
2	Vitamin D FDA LinkGeneric 01/2022 - 09/2020
2	1-phenyl-3,3-dimethyltriazene (PDT)IBA 01/2022 - 10/2014
2	6-methyladenineIBA 01/2022 - 01/2020
2	CollagenIBA 01/2022 - 01/2021
2	Antisense RNA (Anti-Sense RNA)IBA 02/2021 - 10/2019
2	Antineoplastic Agents (Antineoplastics)IBA 01/2021 - 01/2013

Therapy/Procedure

29	Therapeutics 10/2023 - 03/2010
14	Immunotherapy 12/2023 - 06/2019
10	Drug Therapy (Chemotherapy) 12/2023 - 05/2012
6	Radiotherapy 10/2023 - 01/2018
4	Prostheses and Implants (Prosthesis) 01/2022 - 03/2010
4	Limb Salvage 01/2020 - 03/2010
3	Chinese Traditional Medicine (Traditional Chinese Medicine) 04/2023 - 11/2021
3	Craniotomy 01/2020 - 09/2017
3	External Fixators 05/2019 - 04/2009
2	Castration 01/2022 - 08/2019
2	Photochemotherapy (Photodynamic Therapy) 01/2022 - 10/2014